Tissue culture adherence and haemagglutination characteristics of Moraxella (Branhamella) catarrhalis

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Moraxella (Branhamella) catarrhalis bacteremia in an immunocompetent children

Moraxella catarrhalis is an aerobic, Gram-negative diplococcus that commonly inhabits the upper respiratory tract (1). M. catarrhalis is now considered as an important cause of respiratory tract infections in children and adults with chronic obstructive pulmonary disease (COPD) (2, 3, 4). M. catarrhalis is now considered a common cause of otitis media in children and sinusitis in both children ...

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Antigenic heterogeneity and molecular analysis of CopB of Moraxella (Branhamella) catarrhalis.

Outer membrane protein (OMP) CopB, an iron-repressible 81-kDa major OMP of Moraxella (Branhamella) catarrhalis has been a major focus of investigation. To assess CopB as a potential vaccine antigen, we elucidated the degree of antigenic and sequence heterogeneity in this protein among strains of M. catarrhalis. Two monoclonal antibodies, 1F5 and 2.9F, which bind to surface-exposed epitopes on C...

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Purification and characterization of a high-molecular-weight outer membrane protein of Moraxella (Branhamella) catarrhalis.

Moraxella (Branhamella) catarrhalis is an important bacterial cause of otitis media in children and lower respiratory tract infections in adults. In this study, we describe the presence of a novel high-molecular-weight outer membrane protein (HMW-OMP). This protein varies from 350 to 720 kDa in apparent molecular mass among strains by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (S...

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Synthesis and characterization of lipooligosaccharide-based conjugates as vaccine candidates for Moraxella (Branhamella) catarrhalis.

Moraxella (Branhamella) catarrhalis is an important cause of otitis media and sinusitis in children and of lower respiratory tract infections in adults. Lipooligosaccharide (LOS) is a major surface antigen of the bacterium and elicits bactericidal antibodies. Treatment of the LOS from strain ATCC 25238 with anhydrous hydrazine reduced its toxicity 20,000-fold, as assayed in the Limulus amebocyt...

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ژورنال

عنوان ژورنال: FEMS Immunology and Medical Microbiology

سال: 1999

ISSN: 0928-8244

DOI: 10.1016/s0928-8244(99)00015-2